2Q6W

The structure of HLA-DRA, DRB3*0101 (DR52a) with bound platelet integrin peptide associated with fetal and neonatal alloimmune thrombocytopenia

Summary for 2Q6W

• Entry DOI: 10.2210/pdb2q6w/pdb
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB3-1 beta chain, Integrin beta-3, ... (4 entities in total)
• Functional Keywords: drb3, peptide-class ii mhc complex, fetal-maternal alloimmune thrombocytopenia, thrombocytopenia purpura, myasthenia gravis, beta 11 arginine, autoimmunity, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903 P79483; Membrane; Single-pass type I membrane protein: P05106
• Total number of polymer chains: 6
• Total formula weight: 89121.91

Authors

Parry, C.S. (deposition date: 2007-06-05, release date: 2007-07-24, Last modification date: 2023-08-30)

• Primary citation: Parry, C.S.,Gorski, J.,Stern, L.J.; Crystallographic Structure of the Human Leukocyte Antigen DRA, DRB3*0101: Models of a Directional Alloimmune Response and Autoimmunity; J.Mol.Biol., 371:435-446, 2007; PubMed: 17583734; DOI: 10.1016/j.jmb.2007.05.025

Experimental method

X-RAY DIFFRACTION (2.25 Å)