2Q5G

Ligand binding domain of PPAR delta receptor in complex with a partial agonist

Summary for 2Q5G

• Entry DOI: 10.2210/pdb2q5g/pdb
• Related: 2GWX
• Descriptor: Peroxisome proliferator-activated receptor delta, [(7-{[2-(3-MORPHOLIN-4-YLPROP-1-YN-1-YL)-6-{[4-(TRIFLUOROMETHYL)PHENYL]ETHYNYL}PYRIDIN-4-YL]THIO}-2,3-DIHYDRO-1H-INDEN- 4-YL)OXY]ACETIC ACID (2 entities in total)
• Functional Keywords: ppar delta, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q03181
• Total number of polymer chains: 2
• Total formula weight: 66170.43

Authors

Pettersson, I.,Sauerberg, P.,Johansson, E.,Hoffman, I.,Tari, L.W.,Hunter, M.J.,Nix, J. (deposition date: 2007-06-01, release date: 2008-06-03, Last modification date: 2023-08-30)

• Primary citation: Pettersson, I.,Ebdrup, S.,Havranek, M.,Pihera, P.,Korinek, M.,Mogensen, J.P.,Jeppesen, C.B.,Johansson, E.,Sauerberg, P.; Design of a partial PPARdelta agonist.; Bioorg.Med.Chem.Lett., 17:4625-4629, 2007; PubMed: 17560785; DOI: 10.1016/j.bmcl.2007.05.079

Experimental method

X-RAY DIFFRACTION (2.7 Å)