2PX6

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

Summary for 2PX6

• Entry DOI: 10.2210/pdb2px6/pdb
• Descriptor: Thioesterase domain, (2S,3S,5S)-5-[(N-FORMYL-L-LEUCYL)OXY]-2-HEXYL-3-HYDROXYHEXADECANOIC ACID, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (4 entities in total)
• Functional Keywords: thioesaterse domain, orlistat, fatty acid synthase, drug complex, tetrahydrolipstatin, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P49327
• Total number of polymer chains: 2
• Total formula weight: 70644.16

Authors

Pemble IV, C.W.,Johnson, L.C.,Kridel, S.J.,Lowther, W.T. (deposition date: 2007-05-14, release date: 2007-07-10, Last modification date: 2023-08-30)

• Primary citation: Pemble, C.W.,Johnson, L.C.,Kridel, S.J.,Lowther, W.T.; Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat.; Nat.Struct.Mol.Biol., 14:704-709, 2007; PubMed: 17618296; DOI: 10.1038/nsmb1265

Experimental method

X-RAY DIFFRACTION (2.3 Å)