2PT9

The structure of Plasmodium falciparum spermidine synthase in complex with decarboxylated S-adenosylmethionine and the inhibitor cis-4-methylcyclohexylamine (4MCHA)

Summary for 2PT9

Entry DOI	10.2210/pdb2pt9/pdb
Related	2HTE 2I7C 2PSS 2PT6
Descriptor	Spermidine synthase, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, cis-4-methylcyclohexanamine, ... (7 entities in total)
Functional Keywords	transferase, spermidine synthase, structural genomics consortium, sgc, inhibitor complex, structural biology of malarial parasites and other apicomplexans
Biological source	Plasmodium falciparum
Total number of polymer chains	3
Total formula weight	112207.28
Authors	Dufe, V.T.,Qiu, W.,Muller, I.B.,Hui, R.,Walter, R.D.,Al-Karadaghi, S.,Structural Genomics Consortium (SGC) (deposition date: 2007-05-08, release date: 2008-04-01, Last modification date: 2023-08-30)
Primary citation	Dufe, V.T.,Qiu, W.,Muller, I.B.,Hui, R.,Walter, R.D.,Al-Karadaghi, S. Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO. J.Mol.Biol., 373:167-177, 2007 Cited by PubMed: 17822713 DOI: 10.1016/j.jmb.2007.07.053 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation