2PR9

Mu2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with GABAA receptor-gamma2 subunit-derived internalization peptide DEEYGYECL

Summary for 2PR9

• Entry DOI: 10.2210/pdb2pr9/pdb
• Related: 1BW8
• Descriptor: AP-2 complex subunit mu-1, GABA(A) receptor subunit gamma-2 peptide (3 entities in total)
• Functional Keywords: endocytosis, adaptor, internalization peptide complex, inhibitory neurotransmitter receptor
• Biological source: Rattus norvegicus (Norway rat); More
• Cellular location: Cell membrane (By similarity): P84092; Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein: P18508
• Total number of polymer chains: 2
• Total formula weight: 35336.07

Authors

Vahedi-Faridi, A.,Haucke, V.,Kittler, J.T.,Kukhtina, V.,Moss, S.J.,Saenger, W.,Chen, G.-J.,Tretter, V.,Smith, K.,Yan, Z.,McAinsh, K.,Arancibia-Carcamo, L. (deposition date: 2007-05-04, release date: 2008-03-18, Last modification date: 2023-08-30)

• Primary citation: Kittler, J.T.,Chen, G.,Kukhtina, V.,Vahedi-Faridi, A.,Gu, Z.,Tretter, V.,Smith, K.R.,McAinsh, K.,Arancibia-Carcamo, I.L.,Saenger, W.,Haucke, V.,Yan, Z.,Moss, S.J.; Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit.; Proc.Natl.Acad.Sci.Usa, 105:3616-3621, 2008; PubMed: 18305175; DOI: 10.1073/pnas.0707920105

Experimental method

X-RAY DIFFRACTION (2.51 Å)