2PJY

Structural basis for cooperative assembly of the TGF-beta signaling complex

Summary for 2PJY

Entry DOI	10.2210/pdb2pjy/pdb
Descriptor	Transforming growth factor beta-3, TGF-beta receptor type-2, TGF-beta receptor type-1, ... (4 entities in total)
Functional Keywords	ternary complex, three finger toxin, cytokine-cytokine receptor complex, cytokine/cytokine receptor
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P10600 Membrane; Single-pass type I membrane protein: P37173 P36897
Total number of polymer chains	3
Total formula weight	33694.56
Authors	Groppe, J.,Zubieta, C. (deposition date: 2007-04-16, release date: 2008-02-05, Last modification date: 2023-08-30)
Primary citation	Groppe, J.,Hinck, C.S.,Samavarchi-Tehrani, P.,Zubieta, C.,Schuermann, J.P.,Taylor, A.B.,Schwarz, P.M.,Wrana, J.L.,Hinck, A.P. Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol.Cell, 29:157-168, 2008 Cited by PubMed: 18243111 DOI: 10.1016/j.molcel.2007.11.039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation