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2PIN

Thyroid receptor beta in complex with inhibitor

Summary for 2PIN
Entry DOI10.2210/pdb2pin/pdb
Related2PIO 2PIP 2PIQ 2PIR 2PIT 2PIU 2PIV 2PIW 2PIX 2PKL
DescriptorThyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID, 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE, ... (5 entities in total)
Functional Keywordsthyroid receptor beta, nuclear receptors, inhibitors, protein-protein interactions, coregulator binding, af-2 pocket, aromatic-beta-amino ketones, structure-based drug design, surface interacting drugs, hormone receptor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P10828
Total number of polymer chains2
Total formula weight59020.94
Authors
Estebanez-Perpina, E.,Jouravel, N.,Baxter, J.D.,Guy, L.R.,Webb, P.,Fletterick, R.J. (deposition date: 2007-04-13, release date: 2008-02-26, Last modification date: 2024-02-21)
Primary citationEstebanez-Perpina, E.,Arnold, L.A.,Jouravel, N.,Togashi, M.,Blethrow, J.,Mar, E.,Nguyen, P.,Phillips, K.J.,Baxter, J.D.,Webb, P.,Guy, R.K.,Fletterick, R.J.
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor.
Mol.Endocrinol., 21:2919-2928, 2007
Cited by
PubMed: 17823305
DOI: 10.1210/me.2007-0174
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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