2PIN
Thyroid receptor beta in complex with inhibitor
Summary for 2PIN
Entry DOI | 10.2210/pdb2pin/pdb |
Related | 2PIO 2PIP 2PIQ 2PIR 2PIT 2PIU 2PIV 2PIW 2PIX 2PKL |
Descriptor | Thyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID, 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE, ... (5 entities in total) |
Functional Keywords | thyroid receptor beta, nuclear receptors, inhibitors, protein-protein interactions, coregulator binding, af-2 pocket, aromatic-beta-amino ketones, structure-based drug design, surface interacting drugs, hormone receptor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P10828 |
Total number of polymer chains | 2 |
Total formula weight | 59020.94 |
Authors | Estebanez-Perpina, E.,Jouravel, N.,Baxter, J.D.,Guy, L.R.,Webb, P.,Fletterick, R.J. (deposition date: 2007-04-13, release date: 2008-02-26, Last modification date: 2024-02-21) |
Primary citation | Estebanez-Perpina, E.,Arnold, L.A.,Jouravel, N.,Togashi, M.,Blethrow, J.,Mar, E.,Nguyen, P.,Phillips, K.J.,Baxter, J.D.,Webb, P.,Guy, R.K.,Fletterick, R.J. Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Mol.Endocrinol., 21:2919-2928, 2007 Cited by PubMed: 17823305DOI: 10.1210/me.2007-0174 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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