2PIE

Crystal structure of the FHA domain of RNF8 in complex with its optimal phosphopeptide

Summary for 2PIE

• Entry DOI: 10.2210/pdb2pie/pdb
• Related: 2CSW
• Descriptor: E3 ubiquitin-protein ligase RNF8, phosphopeptide (3 entities in total)
• Functional Keywords: fha domain, phosphopeptide, complex, ligase, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : O76064
• Total number of polymer chains: 2
• Total formula weight: 16812.03

Authors

Grant, R.A.,Yaffe, M.B. (deposition date: 2007-04-13, release date: 2007-12-11, Last modification date: 2023-08-30)

• Primary citation: Huen, M.S.,Grant, R.,Manke, I.,Minn, K.,Yu, X.,Yaffe, M.B.,Chen, J.; RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly.; Cell(Cambridge,Mass.), 131:901-914, 2007; PubMed: 18001825; DOI: 10.1016/j.cell.2007.09.041

Experimental method

X-RAY DIFFRACTION (1.35 Å)