2P6X

Crystal structure of human tyrosine phosphatase PTPN22

Summary for 2P6X

• Entry DOI: 10.2210/pdb2p6x/pdb
• Related: 2OC3
• Descriptor: Tyrosine-protein phosphatase non-receptor type 22, 1,2-ETHANEDIOL, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: tyrosine phosphatase, lymphoid phosphatase, pep, lyp, structural genomics, structural genomics consortium, sgc, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q9Y2R2
• Total number of polymer chains: 2
• Total formula weight: 73313.40

Authors

Ugochukwu, E.,Salah, E.,Barr, A.,Shrestha, L.,Alfano, I.,Burgess-Brown, N.,King, O.,Umeano, C.,Papagrigoriou, E.,Pike, A.C.W.,Bunkoczi, G.,Turnbull, A.,Uppenberg, J.,Sundstrom, M.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,von Delft, F.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2007-03-19, release date: 2007-04-03, Last modification date: 2023-08-30)

• Primary citation: Barr, A.J.,Ugochukwu, E.,Lee, W.H.,King, O.N.,Filippakopoulos, P.,Alfano, I.,Savitsky, P.,Burgess-Brown, N.A.,Muller, S.,Knapp, S.; Large-scale structural analysis of the classical human protein tyrosine phosphatome.; Cell(Cambridge,Mass.), 136:352-363, 2009; PubMed: 19167335; DOI: 10.1016/j.cell.2008.11.038

Experimental method

X-RAY DIFFRACTION (1.9 Å)