2P3T

Crystal structure of human factor XA complexed with 3-Chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-6-methoxy-phenyl]-amide

Summary for 2P3T

• Entry DOI: 10.2210/pdb2p3t/pdb
• Related: 1EZQ 1F0R 1F0S 1FJS 1MQ5 1MQ6 2P3U
• Descriptor: Coagulation factor X, CALCIUM ION, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: protein inhibitor complex, nonamidine, coagulation cofactor, protease, blood clotting
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32576.62

Authors

Adler, M.,Whitlow, M. (deposition date: 2007-03-09, release date: 2008-01-22, Last modification date: 2023-08-30)

• Primary citation: Ye, B.,Arnaiz, D.O.,Chou, Y.L.,Griedel, B.D.,Karanjawala, R.,Lee, W.,Morrissey, M.M.,Sacchi, K.L.,Sakata, S.T.,Shaw, K.J.,Wu, S.C.,Zhao, Z.,Adler, M.,Cheeseman, S.,Dole, W.P.,Ewing, J.,Fitch, R.,Lentz, D.,Liang, A.,Light, D.,Morser, J.,Post, J.,Rumennik, G.,Subramanyam, B.,Sullivan, M.E.,Vergona, R.,Walters, J.,Wang, Y.X.,White, K.A.,Whitlow, M.,Kochanny, M.J.; Thiophene-anthranilamides as highly potent and orally available factor xa inhibitors.; J.Med.Chem., 50:2967-2980, 2007; PubMed: 17536795; DOI: 10.1021/jm070125f

Experimental method

X-RAY DIFFRACTION (1.92 Å)