2OVZ

MMP-9 active site mutant with phosphinate inhibitor

Summary for 2OVZ

Entry DOI	10.2210/pdb2ovz/pdb
Related	1GKC 1GKD
Descriptor	Matrix metalloproteinase-9 (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB), ZINC ION, CALCIUM ION, ... (6 entities in total)
Functional Keywords	matrix metalloproteinase, s1-prime pocket, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space, extracellular matrix : P14780
Total number of polymer chains	2
Total formula weight	37668.96
Authors	Tochowicz, A.,Bode, W.,Maskos, K.,Goettig, P. (deposition date: 2007-02-15, release date: 2007-06-19, Last modification date: 2023-08-30)
Primary citation	Tochowicz, A.,Maskos, K.,Huber, R.,Oltenfreiter, R.,Dive, V.,Yiotakis, A.,Zanda, M.,Bode, W.,Goettig, P. Crystal Structures of MMP-9 Complexes with Five Inhibitors: Contribution of the Flexible Arg424 Side-chain to Selectivity. J.Mol.Biol., 371:989-1006, 2007 Cited by PubMed: 17599356 DOI: 10.1016/j.jmb.2007.05.068 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation