2OVQ

Structure of the Skp1-Fbw7-CyclinEdegC complex

Summary for 2OVQ

• Entry DOI: 10.2210/pdb2ovq/pdb
• Related: 2OVP 2OVR
• Descriptor: S-phase kinase-associated protein 1A, F-box/WD repeat protein 7, cyclinE C-terminal degron, ... (5 entities in total)
• Functional Keywords: f-box; wd40 domains; double phosphorylation, transcription-cell cycle complex, transcription/cell cycle
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 1: Nucleus, nucleoplasm . Isoform 2: Cytoplasm . Isoform 3: Nucleus, nucleolus : Q969H0
• Total number of polymer chains: 3
• Total formula weight: 69227.36

Authors

Hao, B.,Oehlmann, S.,Sowa, M.E.,Harper, J.W.,Pavletich, N.P. (deposition date: 2007-02-14, release date: 2007-04-24, Last modification date: 2024-04-03)

• Primary citation: Hao, B.,Oehlmann, S.,Sowa, M.E.,Harper, J.W.,Pavletich, N.P.; Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases; Mol.Cell, 26:131-143, 2007; PubMed: 17434132; DOI: 10.1016/j.molcel.2007.02.022

Experimental method

X-RAY DIFFRACTION (2.6 Å)