2OR4

A high resolution crystal structure of human glutamate carboxypeptidase II in complex with quisqualic acid

Summary for 2OR4

Entry DOI	10.2210/pdb2or4/pdb
Descriptor	Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	prostate specific membrane antigen, metallopeptidase, folate hydrolase, glutamate carboxypeptidase ii, naaladase, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
Total number of polymer chains	1
Total formula weight	82940.01
Authors	Barinka, C.,Lubkowski, J. (deposition date: 2007-02-01, release date: 2007-06-12, Last modification date: 2023-08-30)
Primary citation	Barinka, C.,Rovenska, M.,Mlcochova, P.,Hlouchova, K.,Plechanovova, A.,Majer, P.,Tsukamoto, T.,Slusher, B.S.,Konvalinka, J.,Lubkowski, J. Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. J.Med.Chem., 50:3267-3273, 2007 Cited by PubMed: 17567119 DOI: 10.1021/jm070133w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation