2OF2

crystal structure of furanopyrimidine 8 bound to lck

Summary for 2OF2

Entry DOI	10.2210/pdb2of2/pdb
Related	2OF4
Descriptor	Proto-oncogene tyrosine-protein kinase LCK, 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE (3 entities in total)
Functional Keywords	lck, kinase domain, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P06239
Total number of polymer chains	1
Total formula weight	31744.39
Authors	Martin, M.W. (deposition date: 2007-01-02, release date: 2007-02-27, Last modification date: 2023-08-30)
Primary citation	Martin, M.W.,Newcomb, J.,Nunes, J.J.,Bemis, J.E.,McGowan, D.C.,White, R.D.,Buchanan, J.L.,Dimauro, E.F.,Boucher, C.,Faust, T.,Hsieh, F.,Huang, X.,Lee, J.H.,Schneider, S.,Turci, S.M.,Zhu, X. Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties. Bioorg.Med.Chem.Lett., 17:2299-2304, 2007 Cited by PubMed: 17276681 DOI: 10.1016/j.bmcl.2007.01.048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation