2OBJ

Crystal structure of human PIM-1 Kinase in complex with inhibitor

Summary for 2OBJ

Entry DOI	10.2210/pdb2obj/pdb
Related	1XQZ
Descriptor	Proto-oncogene serine/threonine-protein kinase Pim-1, 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE (3 entities in total)
Functional Keywords	pim, pim-1, pim1, human pim-1 kinase, serine/threonine kinase, kinase inhibitor complex, pyridone, kinase inhibitor, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	38351.27
Authors	Yao, N.,Cheney, I.W.,Yan, S. (deposition date: 2006-12-19, release date: 2007-02-06, Last modification date: 2023-08-30)
Primary citation	Cheney, I.W.,Yan, S.,Appleby, T.,Walker, H.,Vo, T.,Yao, N.,Hamatake, R.,Hong, Z.,Wu, J.Z. Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg.Med.Chem.Lett., 17:1679-1683, 2007 Cited by PubMed: 17251021 DOI: 10.1016/j.bmcl.2006.12.086 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation