2O9I

Crystal Structure of the Human Pregnane X Receptor LBD in complex with an SRC-1 coactivator peptide and T0901317

Summary for 2O9I

Entry DOI	10.2210/pdb2o9i/pdb
Related	1ILG 1ILH 1M13 1NRL 1SKX
Descriptor	Orphan nuclear receptor PXR, Nuclear Receptor Coactivator 1 isoform 3, N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, ... (4 entities in total)
Functional Keywords	nuclear receptor, pregnane x receptor, pxr, t0901317, transcription
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: O75469
Total number of polymer chains	4
Total formula weight	72072.91
Authors	Xue, Y.,Redinbo, M.R. (deposition date: 2006-12-13, release date: 2007-01-30, Last modification date: 2023-08-30)
Primary citation	Xue, Y.,Chao, E.,Zuercher, W.J.,Willson, T.M.,Collins, J.L.,Redinbo, M.R. Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Bioorg.Med.Chem., 15:2156-2166, 2007 Cited by PubMed: 17215127 DOI: 10.1016/j.bmc.2006.12.026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation