2O88

Crystal structure of the N114A mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions

Summary for 2O88

• Entry DOI: 10.2210/pdb2o88/pdb
• Related: 1BBZ
• Descriptor: Proto-oncogene tyrosine-protein kinase ABL1, P41 peptide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: sh3 domain high affinity peptide complex, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• Total number of polymer chains: 4
• Total formula weight: 15022.53

Authors

Camara-Artigas, A. (deposition date: 2006-12-12, release date: 2007-05-01, Last modification date: 2023-08-30)

• Primary citation: Camara-Artigas, A.,Palencia, A.,Martinez, J.C.,Luque, I.,Gavira, J.A.,Garcia-Ruiz, J.M.; Crystallization by capillary counter-diffusion and structure determination of the N114A mutant of the SH3 domain of Abl tyrosine kinase complexed with a high-affinity peptide ligand.; Acta Crystallogr.,Sect.D, 63:646-652, 2007; PubMed: 17452790; DOI: 10.1107/S0907444907011109

Experimental method

X-RAY DIFFRACTION (1.75 Å)