2O65

Crystal structure of Pim1 with Pentahydroxyflavone

Summary for 2O65

Entry DOI	10.2210/pdb2o65/pdb
Related	2O3P 2O63 2O64
Descriptor	Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, 5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, ... (4 entities in total)
Functional Keywords	pim1, pentahydroxyflavone, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	34203.64
Authors	Holder, S.,Zemskova, M.,Zhang, C.,Tabrizizad, M.,Bremer, R.,Neidigh, J.W.,Lilly, M.B. (deposition date: 2006-12-06, release date: 2007-02-13, Last modification date: 2023-12-27)
Primary citation	Holder, S.,Zemskova, M.,Zhang, C.,Tabrizizad, M.,Bremer, R.,Neidigh, J.W.,Lilly, M.B. Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol.Cancer Ther., 6:163-172, 2007 Cited by PubMed: 17218638 DOI: 10.1158/1535-7163.MCT-06-0397 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation