2O64

Crystal structure of Pim1 with Quercetagetin

Summary for 2O64

• Entry DOI: 10.2210/pdb2o64/pdb
• Related: 2O3P 2O63 2O65
• Descriptor: Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, 3,5,6,7-TETRAHYDROXY-2-(3,4-DIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, ... (4 entities in total)
• Functional Keywords: pim1, quercetagetin, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 1
• Total formula weight: 34288.72

Authors

Holder, S.,Zemskova, M.,Zhang, C.,Tabrizizad, M.,Bremer, R.,Neidigh, J.W.,Lilly, M.B. (deposition date: 2006-12-06, release date: 2007-02-13, Last modification date: 2023-12-27)

• Primary citation: Holder, S.,Zemskova, M.,Zhang, C.,Tabrizizad, M.,Bremer, R.,Neidigh, J.W.,Lilly, M.B.; Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase.; Mol.Cancer Ther., 6:163-172, 2007; PubMed: 17218638; DOI: 10.1158/1535-7163.MCT-06-0397

Experimental method

X-RAY DIFFRACTION (2.44 Å)