2O5K
Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor
Summary for 2O5K
Entry DOI | 10.2210/pdb2o5k/pdb |
Descriptor | Glycogen synthase kinase-3 beta, 2-(2,4-DICHLORO-PHENYL)-7-HYDROXY-1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID [2-(4-METHANESULFONYLAMINO-PHENYL)-ETHYL]-AMIDE (2 entities in total) |
Functional Keywords | gsk3beta, benzoimidazol inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P49841 |
Total number of polymer chains | 1 |
Total formula weight | 42784.81 |
Authors | |
Primary citation | Shin, D.,Lee, S.C.,Heo, Y.S.,Lee, W.Y.,Cho, Y.S.,Kim, Y.E.,Hyun, Y.L.,Cho, J.M.,Lee, Y.S.,Ro, S. Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta Bioorg.Med.Chem.Lett., 17:5686-5689, 2007 Cited by PubMed: 17764934DOI: 10.1016/j.bmcl.2007.07.056 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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