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2O21

Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand

Summary for 2O21
Entry DOI10.2210/pdb2o21/pdb
Related2O1Y
DescriptorApoptosis regulator Bcl-2, 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE (2 entities in total)
Functional Keywordsapoptosis, complex, bcl
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion outer membrane; Single-pass membrane protein: P10415
Total number of polymer chains1
Total formula weight19850.13
Authors
Primary citationBruncko, M.,Oost, T.K.,Belli, B.A.,Ding, H.,Joseph, M.K.,Kunzer, A.,Martineau, D.,McClellan, W.J.,Mitten, M.,Ng, S.C.,Nimmer, P.M.,Oltersdorf, T.,Park, C.M.,Petros, A.M.,Shoemaker, A.R.,Song, X.,Wang, X.,Wendt, M.D.,Zhang, H.,Fesik, S.W.,Rosenberg, S.H.,Elmore, S.W.
Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50:641-662, 2007
Cited by
PubMed: 17256834
DOI: 10.1021/jm061152t
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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