2NXX

Crystal Structure of the Ligand-Binding Domains of the T.castaneum (Coleoptera) Heterodimer EcrUSP Bound to Ponasterone A

Summary for 2NXX

Entry DOI	10.2210/pdb2nxx/pdb
Descriptor	Ultraspiracle (USP, NR2B4), Ecdysone Receptor (EcR, NRH1), 2,3,14,20,22-PENTAHYDROXYCHOLEST-7-EN-6-ONE, ... (4 entities in total)
Functional Keywords	hormone receptor, apo and holo ligand binding pocket, hormone-growth factor complex, hormone/growth factor
Biological source	Tribolium castaneum (red flour beetle) More
Cellular location	Nucleus : A1JUG2 A1JUG3
Total number of polymer chains	8
Total formula weight	223683.36
Authors	Iwema, T.,Billas, I.,Moras, D. (deposition date: 2006-11-20, release date: 2007-10-02, Last modification date: 2024-04-03)
Primary citation	Iwema, T.,Billas, I.M.,Beck, Y.,Bonneton, F.,Nierengarten, H.,Chaumot, A.,Richards, G.,Laudet, V.,Moras, D. Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor. Embo J., 26:3770-3782, 2007 Cited by PubMed: 17673910 DOI: 10.1038/sj.emboj.7601810 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation