2NRU

Crystal structure of IRAK-4

Summary for 2NRU

• Entry DOI: 10.2210/pdb2nru/pdb
• Related: 2NRY
• Descriptor: Interleukin-1 receptor-associated kinase 4, SULFATE ION, 1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, irak, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 140265.77

Authors

Wang, Z.,Liu, J.,Walker, N.P.C. (deposition date: 2006-11-02, release date: 2006-12-12, Last modification date: 2023-12-27)

• Primary citation: Wang, Z.,Liu, J.,Sudom, A.,Ayres, M.,Li, S.,Wesche, H.,Powers, J.P.,Walker, N.P.C.; Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.; Structure, 14:1835-1844, 2006; PubMed: 17161373; DOI: 10.1016/j.str.2006.11.001

Experimental method

X-RAY DIFFRACTION (2 Å)