2NPA

the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid

Summary for 2NPA

Entry DOI	10.2210/pdb2npa/pdb
Descriptor	Peroxisome proliferator-activated receptor alpha, SRC- peptide from Nuclear receptor coactivator 1, (2R,3E)-2-{4-[(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)METHOXY]BENZYL}-3-(PROPOXYIMINO)BUTANOIC ACID, ... (4 entities in total)
Functional Keywords	protein-agonist complex, transcription
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: Q07869
Total number of polymer chains	4
Total formula weight	65596.55
Authors	Kim, K.H.,Chung, H.K.,Han, H.O.,Kim, S.H.,Koh, J.S.,Kim, G.T. (deposition date: 2006-10-26, release date: 2007-10-30, Last modification date: 2023-10-25)
Primary citation	Han, H.O.,Kim, S.H.,Kim, K.H.,Hur, G.C.,Yim, H.J.,Chung, H.K.,Woo, S.H.,Koo, K.D.,Lee, C.S.,Koh, J.S.,Kim, G.T. Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists Bioorg.Med.Chem.Lett., 17:937-941, 2007 Cited by PubMed: 17157019 DOI: 10.1016/j.bmcl.2006.11.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation