2NP8

Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors

Summary for 2NP8

Entry DOI	10.2210/pdb2np8/pdb
Related	1MQ4
Descriptor	Serine/threonine-protein kinase 6, SULFATE ION, N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE, ... (4 entities in total)
Functional Keywords	aurora a kinase, aik, aurora 2 kinase, kinase, kinase inhibitor, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, centrosome: O14965
Total number of polymer chains	1
Total formula weight	32045.67
Authors	Tari, L.W.,Hoffman, I.D.,Bensen, D.C.,Hunter, M.J.,Nix, J.,Nelson, K.J.,McRee, D.E.,Swanson, R.V. (deposition date: 2006-10-26, release date: 2006-12-26, Last modification date: 2023-08-30)
Primary citation	Tari, L.W.,Hoffman, I.D.,Bensen, D.C.,Hunter, M.J.,Nix, J.,Nelson, K.J.,McRee, D.E.,Swanson, R.V. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors. Bioorg.Med.Chem.Lett., 17:688-691, 2007 Cited by PubMed: 17157005 DOI: 10.1016/j.bmcl.2006.10.086 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation