2N2W

Solution structure of [B26-B29 triazole cross-linked]-insulin analogue at pH 8.0

Summary for 2N2W

• Entry DOI: 10.2210/pdb2n2w/pdb
• Related: 2N2V 2N2X
• NMR Information: BMRB: 25614
• Descriptor: Insulin A chain, Insulin B chain (2 entities in total)
• Functional Keywords: hormone
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 2
• Total formula weight: 5762.56

Authors

Veverka, V.,Hexnerova, R.,Jiracek, J. (deposition date: 2015-05-15, release date: 2016-02-03)

• Primary citation: Vikova, J.,Collinsova, M.,Kletvikova, E.,Budesinsky, M.,Kaplan, V.,Zakova, L.,Veverka, V.,Hexnerova, R.,Avino, R.J.,Strakova, J.,Selicharova, I.,Vanek, V.,Wright, D.W.,Watson, C.J.,Turkenburg, J.P.,Brzozowski, A.M.,Jiracek, J.; Rational steering of insulin binding specificity by intra-chain chemical crosslinking.; Sci Rep, 6:19431-19431, 2016; PubMed: 26792393; DOI: 10.1038/srep19431

Experimental method

SOLUTION NMR