2MV7

Solution NMR structure of DOT1L in complex with AF9 (DOT1L-AF9)

Summary for 2MV7

• Entry DOI: 10.2210/pdb2mv7/pdb
• Related: 2LM0
• NMR Information: BMRB: 19516
• Descriptor: Protein AF-9, Histone-lysine N-methyltransferase, H3 lysine-79 specific (2 entities in total)
• Functional Keywords: mixed lineage leukemia, leukemia, protein binding-transferase complex, protein binding/transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P42568 Q8TEK3
• Total number of polymer chains: 2
• Total formula weight: 10814.33

Authors

Kuntimaddi, A.,Bushweller, J.H. (deposition date: 2014-09-24, release date: 2015-04-22, Last modification date: 2023-06-14)

• Primary citation: Kuntimaddi, A.,Achille, N.J.,Thorpe, J.,Lokken, A.A.,Singh, R.,Hemenway, C.S.,Adli, M.,Zeleznik-Le, N.J.,Bushweller, J.H.; Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential.; Cell Rep, 11:808-820, 2015; PubMed: 25921540; DOI: 10.1016/j.celrep.2015.04.004

Experimental method

SOLUTION NMR