2MTP

The structure of Filamin repeat 21 bound to integrin

Summary for 2MTP

• Entry DOI: 10.2210/pdb2mtp/pdb
• NMR Information: BMRB: 25176
• Descriptor: Filamin-A, Integrin alpha-IIb, Integrin beta-3 (3 entities in total)
• Functional Keywords: integrin, filamin, protein binding-cell adhesion complex, protein binding/cell adhesion
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cell cortex: P21333; Membrane; Single-pass type I membrane protein: P08514; Cell membrane ; Single- pass type I membrane protein : P05106
• Total number of polymer chains: 3
• Total formula weight: 17962.83

Authors

Liu, J.,Qin, J. (deposition date: 2014-08-28, release date: 2015-04-01, Last modification date: 2023-06-14)

• Primary citation: Liu, J.,Das, M.,Yang, J.,Ithychanda, S.S.,Yakubenko, V.P.,Plow, E.F.,Qin, J.; Structural mechanism of integrin inactivation by filamin.; Nat.Struct.Mol.Biol., 22:383-389, 2015; PubMed: 25849143; DOI: 10.1038/nsmb.2999

Experimental method

SOLUTION NMR