2MRK

Fyn SH2 domain in complex with the natural inhibitory phosphotyrosine peptide

Summary for 2MRK

• Entry DOI: 10.2210/pdb2mrk/pdb
• Related: 2mqi 2mrj
• NMR Information: BMRB: 25082
• Descriptor: Tyrosine-protein kinase Fyn, C-terminal Tyrosine-protein kinase Fyn (2 entities in total)
• Functional Keywords: phosphorylated peptide, fyn kinase, sh2 domain, src kinase, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P06241 P06241
• Total number of polymer chains: 2
• Total formula weight: 12944.54

Authors

Huculeci, R.,Buts, L.,Lenaerts, A.J.,van Nuland, N. (deposition date: 2014-07-09, release date: 2015-07-15, Last modification date: 2016-12-14)

• Primary citation: Huculeci, R.,Cilia, E.,Lyczek, A.,Buts, L.,Houben, K.,Seeliger, M.A.,van Nuland, N.,Lenaerts, T.; Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity.; Structure, 24:1947-1959, 2016; PubMed: 27692963; DOI: 10.1016/j.str.2016.08.016

Experimental method

SOLUTION NMR