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2MGT

Zinc induced dimer of the metal binding domain 1-16 of human amyloid beta-peptide with Alzheimer's disease pathogenic English mutation H6R

Summary for 2MGT
Entry DOI10.2210/pdb2mgt/pdb
NMR InformationBMRB: 19602
DescriptorAmyloid beta A4 protein, ZINC ION (2 entities in total)
Functional Keywordsalzheimer's disease, human amyloid -peptide, zinc binding, protein fibril, metal binding protein
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight4071.69
Authors
Polshakov, V.,Istrate, A.,Kozin, S. (deposition date: 2013-11-06, release date: 2014-11-12, Last modification date: 2020-01-01)
Primary citationIstrate, A.N.,Kozin, S.A.,Zhokhov, S.S.,Mantsyzov, A.B.,Kechko, O.I.,Pastore, A.,Makarov, A.A.,Polshakov, V.I.
Interplay of histidine residues of the Alzheimer's disease A beta peptide governs its Zn-induced oligomerization.
Sci Rep, 6:21734-21734, 2016
Cited by
PubMed: 26898943
DOI: 10.1038/srep21734
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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