2M3I

Characterization of a Novel Alpha4/6-Conotoxin TxIC from Conus textile that Potently Blocks alpha3beta4 Nicotinic Acetylcholine Receptors

Summary for 2M3I

Entry DOI	10.2210/pdb2m3i/pdb
NMR Information	BMRB: 18964
Descriptor	Alpha-conotoxin (1 entity in total)
Functional Keywords	alpha-conotoxin, alpha-helix, disulfide bonds, amidated c-terminus, toxin
Biological source	Conus lividus
Cellular location	Secreted (By similarity): H9N3R7
Total number of polymer chains	1
Total formula weight	1493.82
Authors	Luo, S.,Zhangsun, D.,Zhu, X.,Wu, Y.,Hu, Y.,Christensen, S.,Akcan, M.,Craik, D.J.,McIntosh, J.M. (deposition date: 2013-01-20, release date: 2013-12-04, Last modification date: 2023-06-14)
Primary citation	Luo, S.,Zhangsun, D.,Zhu, X.,Wu, Y.,Hu, Y.,Christensen, S.,Harvey, P.J.,Akcan, M.,Craik, D.J.,McIntosh, J.M. Characterization of a Novel alpha-Conotoxin TxID from Conus textile That Potently Blocks Rat alpha 3 beta 4 Nicotinic Acetylcholine Receptors. J.Med.Chem., 56:9655-9663, 2013 Cited by PubMed: 24200193 DOI: 10.1021/jm401254c PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation