2M27

Major G-quadruplex structure formed in human VEGF promoter, a monomeric parallel-stranded quadruplex

Summary for 2M27

• Entry DOI: 10.2210/pdb2m27/pdb
• Related: 1XAV 2F8U 2L7V 2LBY
• NMR Information: BMRB: 18902
• Descriptor: DNA_(5'-D(*CP*GP*GP*GP*GP*CP*GP*GP*GP*CP*CP*TP*TP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3')_ (1 entity in total)
• Functional Keywords: vegf promoter, g-quadruplex structure, anticancer drug target, parallel g-quadruplex, variable loop interactions, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 6922.41

Authors

Agrawal, P.,Hatzakis, E.,Guo, K.,Carver, M.,Yang, D. (deposition date: 2012-12-14, release date: 2013-09-18, Last modification date: 2023-06-14)

• Primary citation: Agrawal, P.,Hatzakis, E.,Guo, K.,Carver, M.,Yang, D.; Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes.; Nucleic Acids Res., 41:10584-10592, 2013; PubMed: 24005038; DOI: 10.1093/nar/gkt784

Experimental method

SOLUTION NMR