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2M20

EGFR transmembrane - juxtamembrane (TM-JM) segment in bicelles: MD guided NMR refined structure.

Summary for 2M20
Entry DOI10.2210/pdb2m20/pdb
NMR InformationBMRB: 18888
DescriptorEpidermal growth factor receptor (1 entity in total)
Functional Keywordstransmembrane, cell signaling, juxtamembrane, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains2
Total formula weight13558.50
Authors
Primary citationEndres, N.F.,Das, R.,Smith, A.W.,Arkhipov, A.,Kovacs, E.,Huang, Y.,Pelton, J.G.,Shan, Y.,Shaw, D.E.,Wemmer, D.E.,Groves, J.T.,Kuriyan, J.
Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor.
Cell(Cambridge,Mass.), 152:543-556, 2013
Cited by
PubMed: 23374349
DOI: 10.1016/j.cell.2012.12.032
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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