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2M0P

Solution structure of the tenth complement type repeat of human megalin

Summary for 2M0P
Entry DOI10.2210/pdb2m0p/pdb
Related2FYJ 2i1p
NMR InformationBMRB: 18816
DescriptorLow-density lipoprotein receptor-related protein 2, CALCIUM ION (2 entities in total)
Functional Keywordscomplement type repeat, receptor, megalin, ldl receptor family, lrp2, lipid binding protein
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P98164
Total number of polymer chains1
Total formula weight5914.24
Authors
Dagil, R.,Kragelund, B. (deposition date: 2012-11-01, release date: 2013-01-09, Last modification date: 2023-06-14)
Primary citationDagil, R.,O'Shea, C.,Nykjar, A.,Bonvin, A.M.,Kragelund, B.B.
Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin.
J.Biol.Chem., 288:4424-4435, 2013
Cited by
PubMed: 23275343
DOI: 10.1074/jbc.M112.434159
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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