2LZ4

Solution NMR structure of transmembrane domain of amyloid precursor protein V44M

Summary for 2LZ4

• Entry DOI: 10.2210/pdb2lz4/pdb
• Related: 2LZ3
• NMR Information: BMRB: 18648
• Descriptor: Amyloid beta A4 protein (1 entity in total)
• Functional Keywords: helix, dimer, transmembrane, membrane protein
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P05067
• Total number of polymer chains: 2
• Total formula weight: 6350.32

Authors

Chen, W.,Wang, C. (deposition date: 2012-09-23, release date: 2013-10-02, Last modification date: 2023-06-14)

• Primary citation: Chen, W.,Gamache, E.,Rosenman, D.J.,Xie, J.,Lopez, M.M.,Li, Y.M.,Wang, C.; Familial Alzheimer's mutations within APPTM increase A beta 42 production by enhancing accessibility of epsilon-cleavage site.; Nat Commun, 5:3037-3037, 2014; PubMed: 24390130; DOI: 10.1038/ncomms4037

Experimental method

SOLUTION NMR