2LQI

NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2l3b conformation)

Summary for 2LQI

• Entry DOI: 10.2210/pdb2lqi/pdb
• Related: 2LQH
• NMR Information: BMRB: 18315
• Descriptor: CREB-binding protein, Forkhead box O3 (2 entities in total)
• Functional Keywords: promiscuous binding, intrinsic disorder, transcription
• Biological source: Mus musculus (mouse); More
• Cellular location: Cytoplasm (By similarity): P45481
• Total number of polymer chains: 2
• Total formula weight: 15562.38

Authors

Wang, F.,Marshall, C.B.,Yamamoto, K.,Li, G.B.,Gasmi-Seabrook, G.M.C.,Okada, H.,Mak, T.W.,Ikura, M. (deposition date: 2012-03-06, release date: 2012-05-16, Last modification date: 2023-06-14)

• Primary citation: Wang, F.,Marshall, C.B.,Yamamoto, K.,Li, G.Y.,Gasmi-Seabrook, G.M.,Okada, H.,Mak, T.W.,Ikura, M.; Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.; Proc.Natl.Acad.Sci.USA, 109:6078-6083, 2012; PubMed: 22474372; DOI: 10.1073/pnas.1119073109

Experimental method

SOLUTION NMR