2LP2

Solution structure and dynamics of human S100A1 protein modified at cysteine 85 with homocysteine disulfide bond formation in calcium saturated form

Summary for 2LP2

• Entry DOI: 10.2210/pdb2lp2/pdb
• Related: 2L0P
• NMR Information: BMRB: 18230
• Descriptor: Protein S100-A1, 2-AMINO-4-MERCAPTO-BUTYRIC ACID, CALCIUM ION (3 entities in total)
• Functional Keywords: calcium bound form, ef-hand, calcium binding, helix reorientation, signaling protein, thionylation, small thiols, metal binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P23297
• Total number of polymer chains: 2
• Total formula weight: 21281.86

Authors

Nowakowski, M.E.,Jaremko, L.,Jaremko, M.,Zdanowski, K.,Ejchart, A. (deposition date: 2012-01-31, release date: 2013-02-20, Last modification date: 2024-04-03)

• Primary citation: Nowakowski, M.,Ruszczynska-Bartnik, K.,Budzinska, M.,Jaremko, L.,Jaremko, M.,Zdanowski, K.,Bierzynski, A.,Ejchart, A.; Impact of calcium binding and thionylation of S100A1 protein on its nuclear magnetic resonance-derived structure and backbone dynamics.; Biochemistry, 52:1149-1159, 2013; PubMed: 23351007; DOI: 10.1021/bi3015407

Experimental method

SOLUTION NMR