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2LGC

Joint NMR and X-ray refinement reveals the structure of a novel dibenzo[a,d]cycloheptenone inhibitor/p38 MAP kinase complex in solution

Summary for 2LGC
Entry DOI10.2210/pdb2lgc/pdb
NMR InformationBMRB: 6468
DescriptorMitogen-activated protein kinase 14 (1 entity in total)
Functional Keywordsp38 mapk kinase-inhibitor complex, hybrid nmr/x-ray structure, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q16539
Total number of polymer chains1
Total formula weight41208.14
Authors
Habeck, M. (deposition date: 2011-07-25, release date: 2012-07-25, Last modification date: 2023-06-14)
Primary citationHonndorf, V.S.,Coudevylle, N.,Laufer, S.,Becker, S.,Griesinger, C.,Habeck, M.
Inferential NMR/X-ray-based structure determination of a dibenzo[a,d]cycloheptenone inhibitor-p38alpha MAP kinase complex in solution
Angew.Chem.Int.Ed.Engl., 51:2359-2362, 2012
Cited by
PubMed: 22275118
DOI: 10.1002/anie.201105241
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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