2KI6

The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion

Summary for 2KI6

• Entry DOI: 10.2210/pdb2ki6/pdb
• Descriptor: Synaptotagmin-1, Heparin-binding growth factor 1, Protein S100-A13, ... (4 entities in total)
• Functional Keywords: fgf1-s100a13-c2a hetero-hexameric complex, fgf1, s100a13, c2a, calcium, cell junction, cytoplasmic vesicle, glycoprotein, lipoprotein, membrane, metal-binding, palmitate, phosphoprotein, synapse, transmembrane, acetylation, alternative splicing, angiogenesis, developmental protein, differentiation, growth factor, heparin-binding, mitogen, polymorphism, protein transport
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein: P21579; Secreted: P05230; Cytoplasm: Q99584 Q99584
• Total number of polymer chains: 6
• Total formula weight: 82781.22

Authors

Krishna, S.M.,Rani, S.G.,Yu, C. (deposition date: 2009-04-28, release date: 2010-03-09, Last modification date: 2011-07-13)

• Primary citation: Mohan, S.K.,Rani, S.G.,Yu, C.; The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion.; J.Biol.Chem., 285:15464-15475, 2010; PubMed: 20220137; DOI: 10.1074/jbc.M109.066357

Experimental method

SOLUTION NMR