2KBS

Solution structure of harmonin PDZ2 in complex with the carboxyl tail peptide of cadherin23

Summary for 2KBS

• Entry DOI: 10.2210/pdb2kbs/pdb
• Related: 2KBQ 2KBR
• Descriptor: Harmonin, octameric peptide from Cadherin-23 (2 entities in total)
• Functional Keywords: protein complex, alternative splicing, coiled coil, deafness, hearing, non-syndromic deafness, polymorphism, retinitis pigmentosa, sensory transduction, usher syndrome, vision, calcium, cell adhesion, cell membrane, disease mutation, glycoprotein, membrane, phosphoprotein, transmembrane, structural protein-cell adhesion complex, structural protein/cell adhesion
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein (By similarity): Q9H251
• Total number of polymer chains: 2
• Total formula weight: 10593.19

Authors

Pan, L.,Yan, J.,Wu, L.,Zhang, M. (deposition date: 2008-12-05, release date: 2009-03-31, Last modification date: 2022-03-16)

• Primary citation: Pan, L.,Yan, J.,Wu, L.,Zhang, M.; Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23; Proc.Natl.Acad.Sci.USA, 106:5575-5580, 2009; PubMed: 19297620; DOI: 10.1073/pnas.0901819106

Experimental method

SOLUTION NMR