2JXB

Structure of CD3epsilon-Nck2 first SH3 domain complex

Summary for 2JXB

Entry DOI	10.2210/pdb2jxb/pdb
Descriptor	T-cell surface glycoprotein CD3 epsilon chain, Cytoplasmic protein NCK2 (1 entity in total)
Functional Keywords	nck, cd3epsilon, t-cell receptor, sh3 domain, immunology, cytoplasm, sh2 domain, signaling protein complex
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P07766
Total number of polymer chains	1
Total formula weight	10267.66
Authors	Takeuchi, K.,Yang, H.,Ng, E.,Park, S.,Sun, Z.J.,Reinherz, E.L.,Wagner, G. (deposition date: 2007-11-09, release date: 2008-09-23, Last modification date: 2022-03-16)
Primary citation	Takeuchi, K.,Yang, H.,Ng, E.,Park, S.Y.,Sun, Z.Y.,Reinherz, E.L.,Wagner, G. Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity. J.Mol.Biol., 380:704-716, 2008 Cited by PubMed: 18555270 DOI: 10.1016/j.jmb.2008.05.037 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation