2JKM

Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor

Summary for 2JKM

Entry DOI	10.2210/pdb2jkm/pdb
Related	1KTM 1PV3 1QVX 2AEH 2AL6 2J0J 2J0K 2J0L 2J0M 2JKK 2JKO 2JKQ
Descriptor	FOCAL ADHESION KINASE 1, 2-{[5-CHLORO-2-({(1E,4R)-2-METHOXY-4-[(3R)-3-(METHYLAMINO)PYRROLIDIN-1-YL]CYCLOHEXA-2,5-DIEN-1-YLIDENE}AMINO)PYRIMIDIN-4-YL]AMINO}-N-(1-METHYLETHYL)BENZENESULFONAMIDE (3 entities in total)
Functional Keywords	tyrosine-protein kinase, tyrosine- protein kinase, kinase, membrane, transferase, atp-binding, integrin signaling, nucleotide-binding, focal adhesion, cell migration, kinase inhibitor, cell junction, cell membrane, phosphoprotein
Biological source	GALLUS GALLUS (CHICKEN)
Total number of polymer chains	1
Total formula weight	32322.89
Authors	Lietha, D.,Eck, M.J. (deposition date: 2008-08-28, release date: 2008-09-09, Last modification date: 2023-12-13)
Primary citation	Lietha, D.,Eck, M.J. Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation. Plos One, 3:E3800-, 2008 Cited by PubMed: 19030106 DOI: 10.1371/JOURNAL.PONE.0003800 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.31 Å)

Structure validation