2JKK
Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
Summary for 2JKK
Entry DOI | 10.2210/pdb2jkk/pdb |
Related | 1KTM 1PV3 1QVX 2AEH 2AL6 2J0J 2J0K 2J0L 2J0M 2JKM 2JKO 2JKQ |
Descriptor | FOCAL ADHESION KINASE 1, SULFATE ION, 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE, ... (4 entities in total) |
Functional Keywords | tyrosine-protein kinase, tyrosine- protein kinase, kinase, membrane, transferase, atp-binding, integrin signaling, nucleotide-binding, focal adhesion, cell migration, kinase inhibitor, cell junction, cell membrane, phosphoprotein |
Biological source | GALLUS GALLUS (CHICKEN) |
Total number of polymer chains | 1 |
Total formula weight | 32296.80 |
Authors | Lietha, D.,Eck, M.J. (deposition date: 2008-08-28, release date: 2008-09-09, Last modification date: 2023-12-13) |
Primary citation | Lietha, D.,Eck, M.J. Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation. Plos One, 3:E3800-, 2008 Cited by PubMed: 19030106DOI: 10.1371/JOURNAL.PONE.0003800 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report