2JH6

Human Thrombin Hirugen Inhibitor complex

Summary for 2JH6

• Entry DOI: 10.2210/pdb2jh6/pdb
• Related: 2JH0 2JH5
• Descriptor: THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUDIN IIIA, ... (7 entities in total)
• Functional Keywords: glycoprotein, serine protease, kringle, zymogen, thrombin, protease, disease mutation, blood coagulation, gamma-carboxyglutamic acid, protease inhibitor, serine protease inhibitor, sulfation, acute phase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted, extracellular space: P00734 P28507; Secreted: P00734
• Total number of polymer chains: 3
• Total formula weight: 35753.19

Authors

Senger, S.,Chan, C.,Convery, M.A.,Hubbard, J.A.,Young, R.J.,Shah, G.P.,Watson, N.S. (deposition date: 2007-02-20, release date: 2007-05-08, Last modification date: 2013-08-07)

• Primary citation: Senger, S.,Chan, C.,Convery, M.A.,Hubbard, J.A.,Shah, G.P.,Watson, N.S.,Young, R.J.; Sulfonamide-Related Conformational Effects and Their Importance in Structure-Based Design.; Bioorg.Med.Chem.Lett., 17:2931-, 2007; PubMed: 17336062; DOI: 10.1016/J.BMCL.2007.02.034

Experimental method

X-RAY DIFFRACTION (2.21 Å)