2J90

Crystal structure of human ZIP kinase in complex with a tetracyclic pyridone inhibitor (Pyridone 6)

Summary for 2J90

• Entry DOI: 10.2210/pdb2j90/pdb
• Related: 1YRP
• Descriptor: DEATH-ASSOCIATED PROTEIN KINASE 3, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: nuclear protein, nucleotide-binding, serine/threonine- protein kinase, chromatin regulator, myosin phosphorylation, kinase, muscle, apoptosis, transferase, atp-binding
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus: O43293
• Total number of polymer chains: 2
• Total formula weight: 71324.24

Authors

Turnbull, A.P.,Berridge, G.,Fedorov, O.,Pike, A.C.W.,Savitsky, P.,Eswaran, J.,Papagrigoriou, E.,Ugochukwa, E.,von Delft, F.,Gileadi, O.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Sundstrom, M.,Knapp, S. (deposition date: 2006-10-31, release date: 2006-11-07, Last modification date: 2023-12-13)

• Primary citation: Pike, A.C.W.,Rellos, P.,Niesen, F.H.,Turnbull, A.,Oliver, A.W.,Parker, S.A.,Turk, B.E.,Pearl, L.H.,Knapp, S.; Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.; Embo J., 27:704-, 2008; PubMed: 18239682; DOI: 10.1038/EMBOJ.2008.8

Experimental method

X-RAY DIFFRACTION (2 Å)