2J4A

Human Thyroid hormone receptor beta ligand binding domain in complex with KB131084

Summary for 2J4A

Entry DOI	10.2210/pdb2j4a/pdb
Related	1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2H6W 2NLL
Descriptor	THYROID HORMONE RECEPTOR BETA-1, 3,5-DIBROMO-4-(3-ISOPROPYL-PHENOXY)BENZOIC ACID (3 entities in total)
Functional Keywords	nuclear protein, disease mutation, nuclear receptor, zinc, receptor, deafness, zinc-finger, dna-binding, transcription regulation, transcription, alternative splicing, ligand binding domain, polymorphism, metal-binding
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	29013.20
Authors	Farnegardh, M. (deposition date: 2006-08-28, release date: 2007-09-25, Last modification date: 2019-07-24)
Primary citation	Koehler, K.,Gordon, S.,Brandt, P.,Carlsson, B.,Backsbro-Saedi, A.,Apelqvist, T.,Agback, P.,Grover, G.J.,Nelson, W.,Grynfarb, M.,Farnegardh, M.,Rehnmark, S.,Malm, J. Thyroid Receptor Ligands. 6. A High Affinity "Direct Antagonist" Selective for the Thyroid Hormone Receptor. J.Med.Chem., 49:6635-, 2006 Cited by PubMed: 17154490 DOI: 10.1021/JM060521I PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation