Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2J1W

Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D

Summary for 2J1W
Entry DOI10.2210/pdb2j1w/pdb
Related1HU8 1UOL 2BIM 2BIN 2BIO 2BIP 2BIQ 2J1X 2J1Y 2J1Z 2J20 2J21
DescriptorCELLULAR TUMOR ANTIGEN P53, ZINC ION (3 entities in total)
Functional Keywordssecond-site suppressor mutation, disease mutation, nuclear protein, phosphorylation, tumor suppressor, alternative splicing, li-fraumeni syndrome, li- fraumeni syndrome, host-virus interaction, transcription, metal-binding, anti-oncogene, dna-binding, transferase, polymorphism, glycoprotein, zinc, activator, apoptosis, cell cycle, acetylation, p53 dna-binding domain, transcription regulation, superstable mutant, dna-binding protein
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Total number of polymer chains2
Total formula weight49256.40
Authors
Joerger, A.C.,Fersht, A.R. (deposition date: 2006-08-15, release date: 2006-09-20, Last modification date: 2023-12-13)
Primary citationJoerger, A.C.,Ang, H.C.,Fersht, A.R.
Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103:15056-, 2006
Cited by
PubMed: 17015838
DOI: 10.1073/PNAS.0607286103
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon