2J11

p53 tetramerization domain mutant Y327S T329G Q331G

Summary for 2J11

• Entry DOI: 10.2210/pdb2j11/pdb
• Related: 1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2F1X 2FEJ 2J0Z 2J10 3SAK
• NMR Information: BMRB: 7252
• Descriptor: CELLULAR TUMOR ANTIGEN P53 (1 entity in total)
• Functional Keywords: host-virus interaction, nuclear protein, phosphorylation, disease mutation, li-fraumeni syndrome, transcription regulation, transcription, metal-binding, anti-oncogene, dna-binding, glycoprotein, activator, apoptosis, cell cycle
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 4
• Total formula weight: 14299.99

Authors

Carbajo, R.J.,Mora, P.,Sanchez del Pino, M.M.,Perez-Paya, E.,Pineda-Lucena, A. (deposition date: 2006-08-08, release date: 2007-08-28, Last modification date: 2018-04-25)

• Primary citation: Mora, P.,Carbajo, R.J.,Pineda-Lucena, A.,Sanchez del Pino, M.M.,Perez-Paya, E.; Solvent-exposed residues located in the beta-sheet modulate the stability of the tetramerization domain of p53--a structural and combinatorial approach.; Proteins, 71:1670-1685, 2008; PubMed: 18076077; DOI: 10.1002/prot.21854

Experimental method

SOLUTION NMR