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2J10

p53 tetramerization domain mutant T329F Q331K

Summary for 2J10
Entry DOI10.2210/pdb2j10/pdb
Related1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2F1X 2FEJ 2J0Z 2J11 3SAK
NMR InformationBMRB: 7252
DescriptorCELLULAR TUMOR ANTIGEN P53 (1 entity in total)
Functional Keywordsp53, zinc, activator, apoptosis, wild type, cell cycle, acetylation, dna-binding, polymorphism, tetramerization domain, transcription regulation, anti-oncogene, nuclear protein, phosphorylation, li-fraumeni syndrome, host-virus interaction, disease mutation, alternative splicing, glycoprotein, transcription, metal-binding
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Total number of polymer chains4
Total formula weight15253.37
Authors
Carbajo, R.J.,Mora, P.,Sanchez del Pino, M.M.,Perez-Paya, E.,Pineda-Lucena, A. (deposition date: 2006-08-08, release date: 2007-08-28, Last modification date: 2018-04-25)
Primary citationMora, P.,Carbajo, R.J.,Pineda-Lucena, A.,Sanchez del Pino, M.M.,Perez-Paya, E.
Solvent-exposed residues located in the beta-sheet modulate the stability of the tetramerization domain of p53--a structural and combinatorial approach.
Proteins, 71:1670-1685, 2008
Cited by
PubMed: 18076077
DOI: 10.1002/prot.21854
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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