2J0T

Crystal Structure of the Catalytic Domain of MMP-1 in Complex with the Inhibitory Domain of TIMP-1

Summary for 2J0T

• Entry DOI: 10.2210/pdb2j0t/pdb
• Related: 1AYK 1CGE 1CGF 1CGL 1D2B 1HFC 1LQN 1OO9 1SU3 1UEA 2AYK 2CLT 2TCL 3AYK 4AYK 966C
• Descriptor: INTERSTITIAL COLLAGENASE, METALLOPROTEINASE INHIBITOR 1, ZINC ION, ... (5 entities in total)
• Functional Keywords: extracellular matrix, erythrocyte maturation, autocatalytic cleavage, collagen degradation, hydrolase
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted, extracellular space, extracellular matrix (Probable): P03956; Secreted: P01033
• Total number of polymer chains: 6
• Total formula weight: 100551.29

Authors

Iyer, S.,Wei, S.,Brew, K.,Acharya, K.R. (deposition date: 2006-08-04, release date: 2006-10-18, Last modification date: 2023-12-13)

• Primary citation: Iyer, S.,Wei, S.,Brew, K.,Acharya, K.R.; Crystal Structure of the Catalytic Domain of Matrix Metalloproteinase-1 in Complex with the Inhibitory Domain of Tissue Inhibitor of Metalloproteinase-1.; J.Biol.Chem., 282:364-, 2007; PubMed: 17050530; DOI: 10.1074/JBC.M607625200

Experimental method

X-RAY DIFFRACTION (2.54 Å)